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Clomiphene citrate is a well-established medication used for ovulation induction, particularly in women who have ovulatory disorders such as polycystic ovary syndrome (PCOS). It works by acting on the hypothalamus to increase the secretion of gonadotropin-releasing hormone (GnRH), which in turn stimulates the anterior pituitary to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This cascade of hormonal activity promotes follicular development and ovulation.

Clomiphene citrate is typically administered in a cyclical manner and is effective in triggering ovulation in many women, which can lead to improved chances of conception. Its affordability and ease of use make it a first-line treatment for ovulation induction.

While other medications like gonadotropins, metformin, and letrozole can also be utilized for ovulation induction, clomiphene citrate remains one of the most commonly prescribed and widely recognized options for this purpose. Gonadotropins may be used when clomiphene citrate fails, and letrozole is increasingly used as an alternative treatment, particularly in women with PCOS who are resistant to clomiphene. Metformin, primarily an insulin-sensit